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Updated: Jul 18, 2026

Preparation, Purification, and Use of Fatty Acid-containing Liposomes
Published on: February 9, 2018
Nucleolipids: natural occurrence, synthesis, molecular recognition, and supramolecular assemblies as potential
1Katholieke Universiteit Leuven, Dept. Farmaceutische Wetenschappen, Afd. Medicinale Chemie, Minderbroederstraat 10, B-3000 Leuven. helmut.rosemeyer@rega.kuleuven.ac.be
Abstract:
Nucleolipids are hybrid molecules composed of a nucleobase, a nucleoside, a nucleotide or an oligonucleotide (either DNA or RNA), and a lipophilic moiety, which might be either simply a single- or double-chained alkyl (or alkenyl) moiety or a carbocyclic hydrocarbon such as cholesterol, a vitamin, or a bile acid. This review covers all aspects of nucleolipids, namely their natural occurrence, their synthesis, their molecular recognition, as well as aggregation behavior, either in aqueous or non-aqueous solution. Potential future aspects of nucleolipids in material sciences and for the elucidation of biochemical reactions in living cells are discussed.
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