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Published on: October 4, 2019
Two novel trimeric resveratrol derivatives from Cotylelobium lanceolatum
Tetsuro Ito1, Zulfiqar Ali, Miyuki Furusawa
1Gifu Prefectural Institute of Health and Environmental Sciences, 1-1 Naka-fudogaoka, Kakamigahara 504-0838, Japan. zvn00510@nifty.ne.jp
Chemistry & Biodiversity
|December 29, 2006
Summary
Researchers discovered two novel resveratrol trimers, cotylelophenols A and B, from Cotylelobium lanceolatum. These findings expand the known diversity of resveratrol oligomers and propose new biogenetic pathways.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Resveratrol oligomers are a class of compounds with potential biological activities.
- Cotylelobium lanceolatum is a plant species belonging to the Dipterocarpaceae family.
- Isolation and characterization of novel natural products are crucial for drug discovery.
Purpose of the Study:
- To isolate and characterize new resveratrol oligomers from Cotylelobium lanceolatum.
- To elucidate the structures of the isolated compounds using spectroscopic methods.
- To propose potential biogenetic pathways for resveratrol oligomers.
Main Methods:
- Extraction and isolation of compounds from plant material.
- Spectroscopic analyses, including Nuclear Magnetic Resonance (NMR).
- Structure elucidation of novel and known resveratrol oligomers.
Main Results:
- Two new resveratrol trimers, cotylelophenols A (1) and B (2), were identified.
- Ten known resveratrol oligomers (3-12) were also isolated.
- Compound 1 represents the first reported resveratrol trimer with a rearranged 4-hydroxyphenyl group.
- Detailed NMR analysis confirmed the structures of the isolated compounds.
Conclusions:
- The study expands the chemical diversity of resveratrol oligomers.
- Cotylelobium lanceolatum is a source of structurally novel resveratrol derivatives.
- Proposed biogenetic pathways offer insights into the formation of these complex molecules.
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