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Related Experiment Video

Updated: Jul 18, 2026

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

Five new iridoids from Patrinia rupestris.

Xiu-Ping Yang¹, Er-Wei Li, Qi Zhang

¹State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, 730000, PR China.

Chemistry & Biodiversity

|December 29, 2006

Summary

Five new iridoid compounds were discovered in Patrinia rupestris roots, alongside six known ones. Several isolated iridoids demonstrated significant antibacterial activity against common bacterial strains.

Related Experiment Videos

Last Updated: Jul 18, 2026

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

Area of Science:

Phytochemistry
Natural Products Chemistry
Pharmacology

Background:

Patrinia rupestris is a plant species known for its traditional medicinal uses.
Iridoids are a class of monoterpenes found in various plants, often exhibiting biological activities.

Purpose of the Study:

To isolate and characterize new iridoid compounds from Patrinia rupestris roots.
To evaluate the antibacterial potential of the isolated iridoids.

Main Methods:

Isolation of compounds using chromatographic techniques.
Structure elucidation through comprehensive spectroscopic analyses (IR, UV, MS, NMR).
Antibacterial activity testing against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus.

Main Results:

Five new iridoids, named rupesin A-E, were identified.
Six known iridoids were also isolated and characterized.
Compounds 4 and 11 showed activity against Bacillus subtilis.
Compounds 1, 2, 5, 6, 8, 9, and 10 were active against Escherichia coli.
Compounds 3, 4, and 8 exhibited activity against Staphylococcus aureus.

Conclusions:

The study successfully identified novel iridoid structures from Patrinia rupestris.
Several isolated iridoids possess significant broad-spectrum antibacterial properties.
These findings support the potential of Patrinia rupestris as a source of antibacterial agents.