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99mTc(CO)3-VIP analogues: preparation and evaluation as tumor imaging agent
Kanchan Kothari1, Sudhanand Prasad, Aruna Korde
1Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Abstract:
Vasoactive intestinal peptide (VIP) receptors are expressed abundantly on many types of tumors and, hence, radiolabeled VIP analogues are being explored for tumor imaging and therapy. Here, we report synthesis of three VIP analogues and their radiolabeling with (99m)Tc via a novel tricarbonyl synthon. The radiolabeled product could be prepared in high yields (>95%) and stability. In vitro studies showed significant uptake of (99m)Tc(CO)((3))-VP05 in human colon carcinoma cells. Biodistribution studies in animal tumor model showed 0.4-1%ID/g tumor uptake.
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