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Doxapram inhibits the in vitro oxidation of hexobarbital
M Ishikawa1, M Ozaki, Y Takayanagi
1Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.
Research Communications in Chemical Pathology and Pharmacology
|June 1, 1991
Abstract:
The effect of doxapram on the mouse liver microsomal hexobarbital metabolism in vitro was studied. Doxapram inhibited hexobarbital oxidase in a competitive manner, with inhibition constants between 2 and 10 mM. Doxapram induced a reverse type I spectral change with a spectral dissociation constant of about 0.1 microM. These results indicate that doxaprame is an inhibitor of microsomal drug metabolism in the mouse.