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Related Experiment Videos

Major coagulation disorders when using aprotinin--observations on a case.

P Gersbach1, B Lämmle, P Schüpbach

  • 1Department of Thoracic and Cardiovascular Surgery, University of Bern, Inselspital, Switzerland.

The Thoracic and Cardiovascular Surgeon
|August 1, 1991
PubMed
Summary

Aprotinin, a proteinase inhibitor, reduces blood loss during heart surgery. However, it may cause resistance to heparin, an anticoagulant, potentially impacting patient safety.

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Area of Science:

  • Biochemistry
  • Cardiovascular Surgery
  • Pharmacology

Background:

  • Aprotinin is used intraoperatively to minimize blood loss during cardiopulmonary bypass.
  • Potential side effects and drug interactions of aprotinin therapy are not well-documented.
  • Heparin is a standard anticoagulant used in cardiopulmonary bypass procedures.

Observation:

  • A patient receiving prophylactic aprotinin developed resistance to heparin.
  • This heparin resistance persisted for approximately one hour after aprotinin discontinuation.
  • This suggests a possible interaction between aprotinin and heparin.

Findings:

  • Aprotinin administration may interfere with the efficacy of heparin.
  • The interaction appears to manifest as heparin resistance.

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  • The duration of this interaction warrants further investigation.

    • Implications:

    • Clinical protocols may need adjustment regarding concurrent aprotinin and heparin use.
    • Monitoring heparin's effectiveness is crucial in patients receiving aprotinin.
    • Further studies are needed to elucidate the mechanism and clinical significance of this interaction.