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Related Experiment Video

Updated: Apr 28, 2026

Isolation and Culture of Mouse Cortical Astrocytes
11:25

Isolation and Culture of Mouse Cortical Astrocytes

Published on: January 19, 2013

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Granular cell astrocytoma.

En Shin1, Chun Ki Chung, Sung-Hye Park

  • 1Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Pathology, Research and Practice
|January 2, 2007
PubMed
Summary

Granular cell astrocytoma (GCA) is a rare, aggressive brain tumor. This case study highlights its unique ultrastructural features, suggesting mitochondria and paracrystalline inclusions contribute to its granular appearance.

Area of Science:

  • Neuro-oncology
  • Neuropathology
  • Cellular Ultrastructure

Background:

  • Granular cell astrocytoma (GCA) is a rare astrocytoma variant with a poor prognosis.
  • Distinguishing GCA from non-neoplastic conditions like infarcts or demyelinating diseases can be challenging due to similar cytologic and histologic features.
  • This study details a GCA case in a pregnant woman presenting with seizures during delivery.

Observation:

  • Histopathological and immunohistochemical findings were consistent with previous GCA reports.
  • Ultrastructural analysis revealed fewer secondary lysosome granules than expected.
  • Numerous mitochondria and unique paracrystalline inclusions were observed within tumor cells.

Findings:

  • The granular appearance in light microscopy may result from both phagolysosomes and abundant mitochondria/paracrystalline inclusions.

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  • This finding expands the understanding of GCA's cellular composition.
  • The case emphasizes the importance of detailed ultrastructural examination for accurate diagnosis.

    • Implications:

    • Accurate diagnosis of GCA is crucial for appropriate treatment and patient management.
    • Understanding the ultrastructural basis of GCA's appearance can aid in differentiating it from other conditions.
    • Further research into the origin and role of these ultrastructural components is warranted.