Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Inflammation01:38

Inflammation

Overview
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

Health technology assessment (Winchester, England)·2026
Same author

Computed tomography assessment after out-of-hospital cardiac arrest resuscitation.

Resuscitation plus·2026
Same author

Leveraging the shared and opposing genetic mechanisms in the heritable cardiomyopathies.

Research square·2026
Same author

Barriers and Facilitators Towards Physiotherapists' Use of Behaviour Change Techniques (BCTs) to Improve Patients' Adherence to Treatment.

Journal of evaluation in clinical practice·2025
Same author

Clinical and Cardiovascular Magnetic Resonance Characteristics of Veteran Male Endurance Athletes With Atrial Fibrillation: VENTOUX-AF.

Journal of the American Heart Association·2025
Same author

Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice.

Science translational medicine·2025

Related Experiment Video

Updated: Jul 18, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Statins and the vascular endothelial inflammatory response.

John Greenwood1, Justin C Mason

  • 1Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, UK. j.greenwood@ucl.ac.uk

Trends in Immunology
|January 2, 2007
PubMed
Summary

Statins offer more than cholesterol reduction; they possess anti-inflammatory effects beneficial for vascular endothelial cells. These drugs modulate endothelial cell function, impacting inflammatory responses and improving cardiovascular health.

Related Experiment Videos

Last Updated: Jul 18, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Pharmacology

Background:

  • Statins are primarily prescribed to lower cholesterol levels, treating hyperlipidemia and preventing ischemic heart disease.
  • Beyond lipid-lowering, statins exhibit significant immunomodulatory and anti-inflammatory properties.
  • Vascular endothelial cells play a key role in inflammatory disease pathogenesis and are a cellular target for statin therapy.

Purpose of the Study:

  • To investigate the impact of statins on endothelial cell function.
  • To elucidate the mechanisms by which statins exert their therapeutic effects on the endothelium.
  • To understand how statins modulate inflammatory responses within the vasculature.

Main Methods:

  • Analysis of endothelial cell function following statin treatment.
  • Assessment of molecular changes including MHC class II expression, nitric oxide synthase, and fibrinolytic activity.
  • Investigation of leukocyte-endothelial cell interactions and inflammatory gene expression.

Main Results:

  • Statins were found to attenuate endothelial MHC class II expression.
  • Increased endothelial nitric oxide synthase and fibrinolytic activity were observed.
  • Statins decreased leukocyte adhesion and transmigration, enhancing endothelial resistance to injury.
  • These effects are linked to the modulation of small GTPase function and reduced pro-inflammatory gene expression.

Conclusions:

  • Statins' therapeutic benefits extend beyond cholesterol reduction, involving direct actions on endothelial cells.
  • Statins modulate endothelial cell functions to exert anti-inflammatory and immunomodulatory effects.
  • Targeting endothelial cell function with statins represents a key therapeutic strategy for inflammatory vascular diseases.