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Hepatic dysfunction in paediatric typhoidal salmonellosis.

Z A Bhutta¹, S H Naqvi

¹Department of Paediatrics, Aga Khan University and Hospital, Karachi, Pakistan.

Annals of Tropical Paediatrics

|January 1, 1991

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Typhoid can cause significant liver problems in children, with 22% showing impaired liver function. This hepatic dysfunction in pediatric typhoid patients is linked to increased toxicity and mortality.

Area of Science:

Pediatric Infectious Diseases
Hepatology
Clinical Microbiology

Background:

Hepatic dysfunction is documented in adult typhoid cases.
Significant hepatic functional impairment in children with typhoid is rarely reported.

Purpose of the Study:

To investigate the prevalence and clinical significance of hepatic dysfunction in children diagnosed with typhoid fever.

Main Methods:

Retrospective analysis of 435 children with culture-proven typhoid.
Clinical examination for hepatomegaly and right hypochondrial tenderness.
Liver function tests (LFTs) performed on a subset of patients.

Main Results:

Hepatomegaly observed in 29% of children.

Related Experiment Videos

Significant hepatic dysfunction identified in 22% of children undergoing LFTs.

Children with hepatic dysfunction exhibited higher toxicity and mortality rates (p<0.001, p<0.002).

Two cases of fatal fulminant hepatic failure were recorded.

Conclusions:

Hepatic dysfunction is a notable complication in pediatric typhoid.
Impaired liver function in pediatric typhoid is associated with poorer outcomes.
Further research into the mechanisms and management of typhoid-related liver injury in children is warranted.