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Association between blood pressure and serum thyroid-stimulating hormone concentration within the reference range: a
Bjørn O Asvold1, Trine Bjøro, Tom I L Nilsen
1Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway. bjorn.o.asvold@ntnu.no
The Journal of Clinical Endocrinology and Metabolism
|January 4, 2007
Summary
Thyroid stimulating hormone (TSH) within the normal range is linked to higher blood pressure. This association suggests potential long-term cardiovascular health implications, particularly for hypertension risk.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Public Health
Background:
- The relationship between thyroid function and blood pressure requires further investigation.
- Thyroid stimulating hormone (TSH) levels, even within the reference range, may influence cardiovascular parameters.
Purpose of the Study:
- To examine the association between TSH levels within the normal reference range and blood pressure.
- To determine if subclinical variations in TSH impact hypertension risk.
Main Methods:
- A cross-sectional, population-based study was conducted.
- Data from 30,728 individuals without pre-existing thyroid disease were analyzed.
- Systolic, diastolic, and pulse pressures, along with hypertension odds, were assessed against TSH categories.
Main Results:
- A linear positive association was observed between TSH and both systolic and diastolic blood pressure within the reference range (0.50-3.5 mU/liter).
- For every 1 mU/liter increase in TSH, systolic blood pressure increased by approximately 1.8-2.0 mm Hg, and diastolic by 1.1-1.6 mm Hg.
- Individuals in the upper TSH reference range (3.0-3.5 mU/liter) had a significantly higher odds ratio for hypertension compared to those in the lower range (0.50-0.99 mU/liter).
Conclusions:
- A linear positive association exists between TSH and blood pressure within the normal reference range.
- These findings suggest that TSH levels, even within normal limits, may have long-term implications for cardiovascular health and hypertension.
- Further research is warranted to understand the clinical significance of these associations.
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