Related Experiment Video
Updated: Jul 17, 2026

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
Published on: November 11, 2025
[Changes in the pancreas structure after exposure of the body to gravitational overloads]
Abstract:
The aim of this study was to determine the changes in the pancreas structure after acute and chronic exposure of organism to gravitational overloads (GO). The experiments were conducted in 36 outbred albino male rats, 12 rats formed the control group. GO effect was modeled using the centrifuge; the value of the overload thus created amounted to 4,0-6,0 gravitational units. Pancreas structure was studied using histological, electron microscopic and morphometric methods. It was found that after acute exposure to GO, mainly the reactive changes were demonstrated all the pancreatic structures studied: acinocytes, endocrinocytes, blood vessels and nervous apparatus. Chronic exposure to GO resulted in both reactive modifications, similar to those described after an acute exposure, and various compensatory-adaptive and destructive changes.
More Related Videos
07:44Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
Published on: August 7, 2015
16:59Computer-assisted Large-scale Visualization and Quantification of Pancreatic Islet Mass, Size Distribution and Architecture
Published on: March 4, 2011
Related Concept Videos
Chronic Pancreatitis I: Introduction
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...
Chronic Pancreatitis II: Pathophysiology
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Pancreas
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short and...