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Updated: Jul 17, 2026

A Model of Chronic Nutrient Infusion in the Rat
Published on: August 14, 2013
[Structure-functional changes in the rat pancreas after glucose injection]
Abstract:
Electron microscopic method was used to study the effect of hyperglycemia on the pancreas of albino rats (n = 20) after intraperitoneal administration of 40% glucose solution (daily, for 5 days). The data obtained suggest that repeated administration of glucose was accompanied by marked changes in the structure B-endocrinocytes, indicative of the increased secretion of the insulin. This resulted in the appearance of new small pancreatic islets, that consisted of B-endocrinocytes and acino-insular cells. Most frequently acinar-insular cells were located at the periphery of newly formed islets. The latter often had a symplast-type structural organization.
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