Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phase boundaries and biological membranes.

Gerald W Feigenson1

  • 1Field of Biophysics, Cornell University, Ithaca, New York 14853, USA. gwf3@cornell.edu

Annual Review of Biophysics and Biomolecular Structure
|January 5, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma membrane asymmetry and lipid homeostasis: general discussion.

Faraday discussions·2025
Same author

Structure and dynamics of asymmetric membranes: general discussion.

Faraday discussions·2025
Same author

Spiers memorial lecture: Experimental discovery of asymmetric bilayers, and a recent asymmetry example.

Faraday discussions·2025
Same author

An Unexpected Driving Force for Lipid Order Appears in Asymmetric Lipid Bilayers.

Journal of the American Chemical Society·2023
Same author

Nano-scale domains in the plasma membrane are like macroscopic domains in asymmetric bilayers.

Biophysical journal·2022
Same author

Improving our picture of the plasma membrane: Rafts induce ordered domains in a simplified model cytoplasmic leaflet.

Biochimica et biophysica acta. Biomembranes·2022
Same journal

Regulation of actin filament assembly by Arp2/3 complex and formins.

Annual review of biophysics and biomolecular structure·2007
Same journal

Living with noisy genes: how cells function reliably with inherent variability in gene expression.

Annual review of biophysics and biomolecular structure·2007
Same journal

Physics of proteins.

Annual review of biophysics and biomolecular structure·2007
Same journal

Fluorescence correlation spectroscopy: novel variations of an established technique.

Annual review of biophysics and biomolecular structure·2007
Same journal

Structural mechanisms underlying posttranslational modification by ubiquitin-like proteins.

Annual review of biophysics and biomolecular structure·2007
Same journal

From "simple" DNA-protein interactions to the macromolecular machines of gene expression.

Annual review of biophysics and biomolecular structure·2007
See all related articles

Researchers use simple lipid bilayer mixtures to model cell membranes. Understanding complex membrane behavior requires grouping components and determining lipid-protein interactions for accurate modeling.

Area of Science:

  • Biophysics
  • Materials Science
  • Biochemistry

Background:

  • Bilayer lipid mixtures serve as simplified models for complex biological membranes.
  • Cholesterol-containing three-component lipid mixtures exhibit intricate phase behaviors, including two- and three-phase coexistence.
  • The direct applicability of these simple models to biological membranes, with their numerous proteins and lipids, remains unclear.

Purpose of the Study:

  • To bridge the gap between simplified lipid bilayer models and the complexity of biological membranes.
  • To explore methods for grouping diverse cell membrane components to better understand membrane phase behavior.
  • To investigate the potential for modeling lipid and protein distributions in complex membranes through interaction energy determination.

Main Methods:

Related Experiment Videos

  • Observation of phase behavior in three-component bilayer lipid mixtures, including cholesterol.
  • Analysis of phase separation phenomena in model membrane systems.
  • Theoretical considerations for determining lipid-protein interaction energies.

Main Results:

  • Demonstrated rich phase behavior in simple cholesterol-containing lipid mixtures.
  • Identified regions of two-phase and three-phase coexistence in model systems.
  • Highlighted the need for component grouping and interaction energy studies for biological relevance.

Conclusions:

  • Simple lipid mixtures provide a foundation for understanding membrane behavior but require further development for biological accuracy.
  • Grouping membrane components and quantifying lipid-protein interactions are crucial steps toward modeling complex biological membranes.
  • Determining interaction energies could enable predictive modeling of lipid and protein organization within bilayer membranes.