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SNPSTR: a database of compound microsatellite-SNP markers
1Centre for Bioinformatics, Division of Molecular Biosciences, London, UK.
Nucleic Acids Research
|January 5, 2007
Summary
Researchers have developed SNPSTRs, a novel genetic marker combining microsatellites and SNPs. This tool aids in understanding population genetics and evolutionary history across various species.
Area of Science:
- Population Genetics
- Molecular Evolution
- Genomics
Background:
- Genetic markers like single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs) are crucial for population genetic studies.
- Analyzing past demographic events and selection requires robust genetic markers.
Purpose of the Study:
- To introduce and catalogue a new type of compound genetic marker, SNPSTRs.
- To highlight the utility of SNPSTRs for population genetic inferences.
Main Methods:
- Developed a database (SNPSTR database) cataloguing SNPSTRs.
- Defined SNPSTRs as microsatellite markers tightly linked (less than 250 bp apart) with one or more SNPs.
- Ensured no recombination occurs between linked SNP and STR components.
Main Results:
- SNPSTRs function as small haplotypes due to close linkage.
- The SNPSTR database includes human, mouse, rat, dog, and chicken SNPSTRs.
- SNPSTRs offer potential as a valuable tool in population genetics.
Conclusions:
- SNPSTRs represent a novel and powerful genetic marker for population genetics.
- The SNPSTR database provides a comprehensive resource for multiple species.
- SNPSTRs can enhance the study of population history and selection effects.
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