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Study of growth in prepubertal asthmatics

N F Ismail1, S M Aly, M O Abdu

  • 1University of Alexandria, Alexandria, Egypt. nevinenola@yahoo.co.uk

Indian Journal of Pediatrics
|January 5, 2007
PubMed

Insights

Long-standing asthma in children did not significantly impact physical growth but did influence skeletal maturation. Early asthma onset correlated with height in asthmatic children.

Area of Science:

  • Pediatric Endocrinology
  • Respiratory Medicine
  • Child Growth and Development

Background:

  • Asthma is a common chronic respiratory disease in children.
  • The potential impact of asthma on growth, particularly before corticosteroid treatment, requires further investigation.

Purpose of the Study:

  • To evaluate the effect of long-standing asthma on physical and skeletal growth in prepubertal Egyptian children.
  • To compare growth parameters between children with moderate to severe asthma and healthy controls.

Main Methods:

  • A pilot study involving prepubertal children with asthma (moderate n=24, severe n=14) and a control group (n=15).
  • Assessment of physical growth (weight, height, BMI, etc.) and skeletal growth using standard deviation scores (SDS).
  • Statistical analysis using one-way ANOVA to compare groups.

Main Results:

  • No significant differences in physical growth parameters (weight, height, BMI, skin fold thickness) between asthmatic and control groups.
  • A positive correlation was observed between the age of asthma onset and height in asthmatic children (r=0.288, p=0.036).
  • Bone age SDS showed significant differences between asthmatic groups (moderate and severe) and controls (P<0.05), indicating altered skeletal maturation.

Conclusions:

  • Asthma itself does not appear to significantly affect major physical growth parameters in children.
  • Long-standing asthma can influence skeletal maturation, as indicated by bone age differences.
Abstract

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