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Study of growth in prepubertal asthmatics
N F Ismail1, S M Aly, M O Abdu
1University of Alexandria, Alexandria, Egypt. nevinenola@yahoo.co.uk
Indian Journal of Pediatrics
|January 5, 2007
Summary
Long-standing asthma in children did not significantly impact physical growth but did influence skeletal maturation. Early asthma onset correlated with height in asthmatic children.
Area of Science:
- Pediatric Endocrinology
- Respiratory Medicine
- Child Growth and Development
Background:
- Asthma is a common chronic respiratory disease in children.
- The potential impact of asthma on growth, particularly before corticosteroid treatment, requires further investigation.
Purpose of the Study:
- To evaluate the effect of long-standing asthma on physical and skeletal growth in prepubertal Egyptian children.
- To compare growth parameters between children with moderate to severe asthma and healthy controls.
Main Methods:
- A pilot study involving prepubertal children with asthma (moderate n=24, severe n=14) and a control group (n=15).
- Assessment of physical growth (weight, height, BMI, etc.) and skeletal growth using standard deviation scores (SDS).
- Statistical analysis using one-way ANOVA to compare groups.
Main Results:
- No significant differences in physical growth parameters (weight, height, BMI, skin fold thickness) between asthmatic and control groups.
- A positive correlation was observed between the age of asthma onset and height in asthmatic children (r=0.288, p=0.036).
- Bone age SDS showed significant differences between asthmatic groups (moderate and severe) and controls (P<0.05), indicating altered skeletal maturation.
Conclusions:
- Asthma itself does not appear to significantly affect major physical growth parameters in children.
- Long-standing asthma can influence skeletal maturation, as indicated by bone age differences.
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