Related Experiment Video
Updated: Jul 17, 2026
08:39
Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
Published on: January 7, 2019
[Lymphocyte trafficking and immunesurveillance]
Toshiyuki Tanaka1, Eiji Umemoto, Masayuki Miyasaka
1Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine.
Summary
Immune system balance relies on lymphocyte recirculation. Activated lymphocytes change how they move, guided by specific signals to lymphoid and non-lymphoid tissues for immune responses.
Area of Science:
- Immunology
- Cell Biology
- Vascular Biology
Context:
- Immune homeostasis depends on lymphocyte movement between blood and tissues.
- Lymphocytes recirculate through secondary lymphoid organs (lymph nodes, spleen, Peyer's patches).
- Antigen encounter alters lymphocyte trafficking, enabling effector functions in various tissues.
Purpose:
- To review the mechanisms governing lymphocyte recirculation and tissue-specific trafficking.
- To highlight the role of endothelial cells and molecular cues in directing lymphocyte migration.
- To explain how lymphocytes exit lymphoid and extralymphoid tissues.
Summary:
- Naive lymphocyte recirculation is vital for immune homeostasis.
- Activated lymphocytes reprogram their trafficking, guided by endothelial cells and chemokines.
- Specific receptors regulate lymphocyte exit from tissues into circulation.
Impact:
- Provides a comprehensive overview of lymphocyte trafficking regulation.
- Enhances understanding of immune cell migration in health and disease.
- Informs strategies for modulating immune responses through targeted cell delivery.
Related Concept Videos
01:28Functions of the Lymphatic and Immune System
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
01:23Introduction to Lymphatic and Immune System
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
01:25Immune Surveillance by NK Cells and Phagocytes
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
01:40Cell-mediated Immune Responses
Overview
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...