Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel gene switches.

W Weber1, M Fussenegger

  • 1Institute for Chemical and Bioengineering, ETH Zurich, ETH Hoenggerberg HCI F 115, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.

Handbook of Experimental Pharmacology
|January 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation.

Cytotechnology·2008
Same author

Regulated multicistronic expression technology for mammalian metabolic engineering.

Cytotechnology·2008
Same author

pQuattro vectors allow one-step multigene metabolic engineering and auto-selection of quattrocistronic artificial mammalian operons.

Cytotechnology·2008
Same author

A novel cytostatic process enhances the productivity of Chinese hamster ovary cells.

Biotechnology and bioengineering·2008
Same author

Cell recordings with a CMOS high-density microelectrode array.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2007
Same author

Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence.

World journal of urology·2007
Same journal

Endothelial Cell Phenotypic Plasticity in Atherosclerosis.

Handbook of experimental pharmacology·2026
Same journal

Endothelial Dysfunction and Neurovascular Alterations in Autism Spectrum Disorder.

Handbook of experimental pharmacology·2026
Same journal

Molecular Mechanisms of Endothelial Shear Stress Mechanotransduction in Health and Disease.

Handbook of experimental pharmacology·2026
Same journal

Microvasculature of the Pancreatic Islets of Langerhans in Health and Diabetes.

Handbook of experimental pharmacology·2026
Same journal

Mechanisms of Actions of Physiological, Pharmacological, and Toxicological Dietary Bioactive Inorganic Boron.

Handbook of experimental pharmacology·2026
Same journal

BNCT Plus Luminescence: New Paradigm for Boron-Containing Drug Design.

Handbook of experimental pharmacology·2026
See all related articles

Precise control over gene activity is crucial for therapeutics and research. This review covers recent advances in gene switches and synthetic biology for precise gene regulation and protein production.

Area of Science:

  • Molecular Biology
  • Synthetic Biology
  • Biotechnology

Background:

  • Precise control of gene activity is essential for various applications, including gene therapy, bioengineering, and drug discovery.
  • Developing sophisticated methods to regulate gene expression and protein production is a key area of research.

Purpose of the Study:

  • To provide a comprehensive overview of current strategies for controlling gene activity and protein formation.
  • To highlight recent advancements in gene switch technology and mammalian synthetic biology.
  • To summarize applications of gene switches in gene therapy, bioengineering, and drug discovery.

Main Methods:

  • Review of genomic rearrangements, transcriptional, and translational control mechanisms.
  • Analysis of inducible secretion and protein activity engineering.

Related Experiment Videos

  • Focus on developments in gene switch design and mammalian synthetic biology over the past two years.

    • Main Results:

    • Recent gene switches utilize novel inducer routes (e.g., gas phase) and integrate heterologous switches with endogenous signals.
    • Mammalian synthetic biology enables the design of complex synthetic and semisynthetic gene networks.
    • Diverse applications in gene therapy, bioengineering, and drug discovery have been demonstrated.

    Conclusions:

    • Gene switches and synthetic biology offer powerful tools for precise spatiotemporal control of gene expression.
    • Continued innovation in these fields promises to advance therapeutic and research applications.
    • The integration of engineered gene networks is a rapidly growing area with significant potential.