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Cell recordings with a CMOS high-density microelectrode array.

U Frey1, C D Sanchez-Bustamante, T Ugniwenko

  • 1Physical Electronics Lab, ETH Zurich, Worlfgang-Pauli-Str., 16, 8093 Zurich, Switzerland. ufrey@phys.ethz.ch

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 16, 2007
PubMed
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This study introduces a high-resolution CMOS-based microelectrode array (MEA) for advanced electrophysiology. The MEA enables detailed recordings from various excitable cells, including neurons and cardiomyocytes.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Electrophysiology

Background:

  • Microelectrode arrays (MEAs) are crucial for studying electrogenic cells.
  • Existing MEAs may lack sufficient spatial resolution or flexibility for complex biological preparations.

Purpose of the Study:

  • To develop and characterize a novel CMOS-based MEA with high spatial resolution and reconfigurable channel routing.
  • To demonstrate the MEA's capability for recording from diverse excitable cell types.

Main Methods:

  • Utilized a CMOS-based microelectrode array (MEA) with 11,016 electrodes and 126 channels.
  • Achieved high spatial resolution (3,200 electrodes/mm²) with 7 µm electrode diameter and 18 µm pitch.
  • Configured reconfigurable electrode routing for flexible data acquisition.

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  • Performed extracellular recordings from neonatal rat cardiomyocytes and dissociated rat hippocampal neurons, as well as acute cerebellar slices.

    • Main Results:

    • Demonstrated high-fidelity extracellular recordings from neonatal rat cardiomyocytes in confluent layers and microtissues.
    • Successfully captured neural signals from dissociated rat hippocampal neurons.
    • Presented electrophysiological data from neurons within an acute cerebellar slice preparation.

    Conclusions:

    • The developed CMOS-based MEA offers high spatial resolution and flexible channel routing for advanced electrophysiological studies.
    • The device is suitable for recording from various excitable cell types, including cardiomyocytes and neurons.
    • This technology advances the ability to investigate cellular communication and network activity in complex biological systems.