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Different isoforms of apolipoprotein AI present heterologous post-translational expression in HIV infected patients
Sung-Soon Kim1, Mi-Hye Kim, Bo-Kyung Shin
1Department of Virology, National Institute of Health, Seoul 122-701, Korea.
Abstract:
Human immunodeficiency virus (HIV) is rapidly becoming a global health concern. Proteomics technology was employed to examine HIV infected plasma samples in an attempt to identify disease-associated proteins. By comparison with normal and HIV positive plasma samples, at least eight proteins were significantly changed in HIV infected plasma. In particular, apolipoprotein AI presents a heterogeneous change in expression level with different isoforms. Apolipoprotein AI could be a useful biomarker for HIV diagnosis.
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