Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Physiology of the Gastrointestinal System II: Digestion and Absorption

Physiology of the Gastrointestinal System II: Digestion and Absorption

The gastrointestinal (GI) tract, extending from the mouth to the anus, plays a pivotal role in the digestion and absorption of nutrients. This process involves both mechanical and chemical actions facilitated by various enzymes.
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

Factors Influencing Drug Absorption: Disease States and Pharmacology

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...

Absorption of Nutrients

Absorption of Nutrients

Absorption refers to taking dietary nutrients from the intestinal lumen for transportation throughout the body. After digestion in the small intestine, carbohydrates, proteins, and fats are broken down into simpler forms. These essential macronutrients and other vital substances, such as vitamins, minerals, and water, are then prepared for absorption into the bloodstream.
Enterocytes, which are specialized polar epithelial cells, line the mucosa of the small intestinal walls. These cells...

Dysbiosis of the Gut Microbiota

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...

Inflammatory Bowel Disease II: Ulcerative Colitis

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multiplexed Imaging Strategy to Distinguish Indeterminant Biliary Strictures: An <i>Ex Vivo</i> Study.

World journal of gastroenterology, hepatology and endoscopy·2022

Same author

Artificial intelligence for detection of microsatellite instability in colorectal cancer-a multicentric analysis of a pre-screening tool for clinical application.

ESMO open·2022

Same author

An increased proportion of inflammatory cells express tumor necrosis factor alpha in idiopathic achalasia of the esophagus.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2009

Same author

Cat scratch colon.

Endoscopy·2007

Same author

The use of laparoscopic liver biopsies in pediatric patients with hepatic dysfunction following allogeneic hematopoietic stem cell transplantation.

Bone marrow transplantation·2005

Same author

Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.

Gut·2003

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

The pathology of malabsorption: current concepts.

S R Owens¹, J K Greenson

¹Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

|January 6, 2007

Summary

Intestinal malabsorption has diverse causes, categorized into maldigestion, mucosal/mural issues, and microbial factors. Understanding these groups is key for diagnosing and managing malabsorption syndromes.

Area of Science:

Gastroenterology
Internal Medicine
Pathophysiology

Background:

Intestinal malabsorption presents with varied etiologies.
Classification aids in understanding complex causes.
Focus on mucosal and microbial factors is crucial.

Purpose of the Study:

To categorize the causes of intestinal malabsorption.
To provide an overview of common and significant malabsorption entities.
To discuss current concepts in malabsorption.

Main Methods:

Literature review and synthesis of existing knowledge.
Categorization of malabsorption causes into three main groups.
Focused discussion on mucosal and microbial etiologies.

More Related Videos

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

Published on: November 30, 2022

Related Experiment Videos

Last Updated: Jul 11, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

Published on: November 30, 2022

Main Results:

Identified three primary categories: maldigestion, mucosal/mural causes, and microbial causes.
Detailed examples within each category, including enzyme deficiencies, enteropathies, and infections.
Highlighted specific conditions like gluten-sensitive enteropathy and bacterial overgrowth.

Conclusions:

Effective management of intestinal malabsorption requires understanding its diverse origins.
Mucosal and microbial causes represent significant and complex areas of malabsorption.
Further research into these specific categories is warranted.