Disturbed glucose metabolism is associated with left ventricular dysfunction using tissue Doppler imaging in patients...

Area of Science:

• Cardiology
• Metabolic Disorders
• Diagnostic Imaging

Background:

• Myocardial infarction (MI) survivors without diabetes may still experience cardiac dysfunction.
• Glucose metabolism plays a crucial role in cardiovascular health.
• Tissue Doppler imaging (TDI) is a valuable tool for assessing left ventricular (LV) function.

Purpose of the Study:

• To examine the relationship between glucose abnormalities and LV function in MI patients without known diabetes.
• To utilize TDI to quantify LV functional parameters in relation to glucose metabolism.
• To identify potential early indicators of cardiac dysfunction in post-MI patients with glucose dysregulation.

Main Methods:

• A cross-sectional study involving 123 patients with a history of MI and no known diabetes.
• TDI echocardiography was performed to assess LV function.
• An oral glucose tolerance test (OGTT) was administered to evaluate glucose metabolism.

Main Results:

• Abnormal glucose metabolism was significantly associated with impaired LV function, indicated by altered LV ejection time, early diastolic filling velocity (E'-v), E'/A' ratio, and myocardial performance index (MPI).
• Patients with disturbed glucose metabolism exhibited significantly lower E'/A' and E'-v, and higher MPI compared to those with normal glucose tolerance.
• These findings persisted even after excluding patients with diagnosed diabetes mellitus.

Conclusions:

• Disturbed glucose metabolism, encompassing impaired glucose tolerance and prediabetes, is associated with significant left ventricular dysfunction in myocardial infarction survivors.
• TDI can detect LV functional abnormalities related to glucose metabolism in this patient population.
• Early identification and management of glucose abnormalities may be crucial for improving cardiac outcomes in post-MI patients.