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Neogenin: A multi-functional receptor regulating diverse developmental processes.

Stacey J Cole1, Danakai Bradford, Helen M Cooper

  • 1The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia. s.cole@uq.edu.au

The International Journal of Biochemistry & Cell Biology
|January 6, 2007
PubMed
Summary
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Neogenin acts as a receptor for Netrin and Repulsive Guidance Molecule (RGM) families, influencing axon guidance and developmental processes. Emerging research also highlights its novel role in regulating iron homeostasis in adults.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Neuroscience

Background:

  • Neogenin, a receptor related to DCC, binds Netrin and RGM families.
  • Netrin-1 binding promotes chemoattraction, while RGMa binding induces chemorepulsion.
  • Neogenin regulates diverse developmental processes like neural tube and mammary gland formation, myogenesis, and angiogenesis.

Purpose of the Study:

  • To explore the multi-functional roles of Neogenin beyond axon guidance.
  • To investigate the emerging function of Neogenin in adult iron homeostasis.
  • To understand the context-dependent signaling pathways activated by Neogenin.

Main Methods:

  • Literature review of Neogenin's known interactions and functions.
  • Analysis of accumulating evidence on Neogenin's role in development and adult physiology.

Related Experiment Videos

  • Exploration of signaling pathways downstream of Neogenin activation.

    • Main Results:

    • Neogenin mediates both attractive (Netrin-1) and repulsive (RGMa) axon guidance.
    • Neogenin is implicated in various developmental events, including neural tube and mammary gland development, myogenesis, and angiogenesis.
    • A novel role for Neogenin in regulating adult iron homeostasis is emerging.

    Conclusions:

    • Neogenin is a versatile receptor with diverse roles in embryonic development.
    • The functional outcome of Neogenin activation is context- and ligand-dependent.
    • Neogenin's function in adult iron homeostasis warrants further investigation.