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09:43
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Systemic polyarteritis nodosa associated with acute Epstein-Barr virus infection
Teresa Caldeira1, Carla Meireles, Francisco Cunha
1Pediatric Intensive Care Unit, UAG-MC, Hospital S. João, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal. caldeira.teresa@gmail.com
Clinical Rheumatology
|January 6, 2007
Summary
This case report details a child with Polyarteritis Nodosa (PAN), a rare vasculitis, who developed severe symptoms including shock and kidney failure. The condition was linked to an active Epstein-Barr virus (EBV) infection.
Area of Science:
- Pediatric Rheumatology
- Infectious Diseases
- Nephrology
Background:
- Polyarteritis nodosa (PAN) is a rare systemic vasculitis affecting medium and small arteries in children.
- Early diagnosis and treatment are crucial for managing PAN and preventing severe complications.
Observation:
- A child presented with prolonged fever, shock, acute renal failure, nephrotic-range proteinuria, hypertension, and altered consciousness.
- Cranial tomography showed a left hemorrhagic lesion, and renal biopsy confirmed fibrinoid necrosis consistent with PAN.
Findings:
- Active Epstein-Barr virus (EBV) infection was identified as a potential trigger for PAN in this patient.
- The patient showed a positive response to treatment with oral prednisolone and intravenous cyclophosphamide.
Implications:
- This case highlights a potential association between active EBV infection and childhood PAN.
- Successful treatment suggests a viable therapeutic approach for EBV-related PAN.
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