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Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
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Multiple organ failure during primary HIV infection.

Pierre Tattevin1, Christophe Camus, Cédric Arvieux

  • 1Service de Maladies Infectieuses et Reanimation Medicale, Pontchaillou University Hospital, Rennes, 35033, France. pierre.tattevin@chu-rennes.fr

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
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PubMed
Summary

Primary HIV infection can present unusually, sometimes leading to severe complications. This case highlights multiple organ failure as a rare but critical manifestation of early human immunodeficiency virus infection.

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Area of Science:

  • Infectious Diseases
  • Virology
  • Immunology

Background:

  • Primary HIV infection, the earliest stage of human immunodeficiency virus (HIV) infection, presents with a wide spectrum of clinical manifestations.
  • Symptoms can range from asymptomatic to a mononucleosis-like illness, with some patients experiencing severe, atypical presentations.

Observation:

  • This report details a rare case of multiple organ failure occurring during the primary stage of HIV infection.
  • The patient exhibited severe, life-threatening complications beyond the typical symptoms associated with early HIV.

Findings:

  • Multiple organ failure represents an extreme and uncommon manifestation of primary HIV infection.
  • This presentation underscores the potential for severe systemic illness even in the initial phase of HIV.

Implications:

  • Early recognition of severe presentations of primary HIV infection is crucial for timely intervention.
  • Understanding these rare but severe manifestations can improve diagnostic strategies and patient outcomes in HIV care.
  • This case emphasizes the need for a high index of suspicion for HIV in patients with unexplained multiple organ failure.