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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Celiprolol-induced lupus-like syndrome
Jean-Christophe Charniot1, Thierry Genereau, Luc Mouthon
1Department of Cardiology, Avicenne Hospital, Bobigny, France. jean-christophe.charniot@avc.ap-hop-paris.fr
Acta Cardiologica
|January 9, 2007
Summary
Celiprolol, a beta-blocker, may induce a lupus-like syndrome. A 67-year-old woman developed symptoms including joint pain and pericarditis after two years of celiprolol use, requiring prolonged steroid treatment.
Area of Science:
- Rheumatology
- Clinical Pharmacology
Background:
- Systemic lupus erythematosus (SLE) is an autoimmune disease with idiopathic or drug-induced origins.
- Beta-blockers are known to occasionally cause drug-induced lupus erythematosus (DILE).
Observation:
- A 67-year-old female patient presented with symptoms suggestive of a lupus-like syndrome.
- The patient had been taking celiprolol for two years prior to symptom onset.
Findings:
- The patient developed febrile polyarthritis, pericarditis, and positive antinuclear and anti-histone antibodies.
- These findings are consistent with a drug-induced lupus-like syndrome.
- Celiprolol was identified as the likely causative agent, as no previous cases linked to this specific beta-blocker have been reported.
Implications:
- This case highlights celiprolol as a potential cause of drug-induced lupus erythematosus.
- Physicians should consider celiprolol when evaluating patients presenting with lupus-like symptoms.
- Management required prolonged corticotherapy even after drug withdrawal, indicating potential severity.
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