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Genetic risk factors in patients with inflammatory bowel disease and vascular complications: case-control study

I E Koutroubakis1, A Sfiridaki, G Tsiolakidou

  • 1Department of Gastroenterology University Hospital Heraklion, Crete, Greece. ktjohn@her.forthnet.gr

Inflammatory Bowel Diseases
|January 9, 2007
PubMed

Insights

Genetic mutations in Factor V (FV) and plasminogen activator inhibitor (PAI)-1 may increase the risk of vascular complications in inflammatory bowel disease (IBD) patients. These genetic factors were found to be more common in IBD patients with vascular issues than in healthy individuals.

Area of Science:

  • Genetics
  • Gastroenterology
  • Cardiology

Background:

  • Inherited risk factors are implicated in inflammatory bowel disease (IBD) vascular complications.
  • Investigating specific gene mutations in IBD patients with and without vascular issues is crucial.

Purpose of the Study:

  • To examine the role of cardiovascular disease-associated mutations in IBD patients.
  • Compare mutation carriage in IBD patients with vascular complications (IBD-VC) against IBD patients without vascular complications, thrombotic controls (TC), and healthy controls (HC).

Main Methods:

  • Evaluated twelve polymorphisms in thrombophilic and vasoactive genes.
  • Compared mutation frequencies across four groups: IBD-VC (n=30), IBD (n=60), TC (n=30), and HC (n=54).

Main Results:

  • Factor V (FV) R506Q genotype and 506Q allele frequencies were higher in IBD-VC and TC groups compared to HC.
  • Plasminogen activator inhibitor (PAI)-1 4G allele frequency was significantly higher in IBD-VC and TC groups versus IBD and HC groups.
  • A trend suggested FV R506Q association with venous thrombosis and PAI-1 with arterial thrombosis.

Conclusions:

  • Investigated gene polymorphisms did not differ between IBD-VC and TC groups.
  • FV R506Q and PAI-1 gene polymorphisms may be linked to an increased risk of vascular complications in IBD.
Abstract

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