Histocompatibility class I and II antigens in extensive kindred with Sneddon's syndrome and related hypercoagulation
Manuel Lousa1, Ana Pardo, Antonio Arnaiz-Villena
1S. de Neurología, Hospital Insular, Las Palmas, Spain.
Abstract:
We have studied the relationship between the histocompatibility class I and II antigens and Sneddon's syndrome (SS) in a Spanish patient with SS and her relatives (13 available members of an extensive 3-generation pedigree with diverse autoimmune hypercoagulation abnormalities). The patient and her father were diagnosed with a primary antiphospholipid antibody syndrome and were HLA-A30-B13-Bw6. In addition, a HLA-Bw6-DQ1 association was present in all the members of this kindred. These data suggest that the combination of the histocompatibility class I and II antigens in this family may be a marker for predisposition to SS.
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