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Corticotrophin after corticosteroids in children with asthma and growth retardation
British Journal of Diseases of the Chest
|July 1, 1975
Insights
Growth in children with chronic asthma slowed on prednisolone but improved after switching to corticotrophin. This study highlights the impact of corticosteroid type on pediatric growth.
Area of Science:
- Pediatric Endocrinology
- Respiratory Medicine
- Pharmacology
Background:
- Chronic asthma often requires long-term corticosteroid treatment.
- Prednisolone is a commonly used corticosteroid for asthma management.
- Growth retardation is a potential side effect of prolonged corticosteroid use in children.
Purpose of the Study:
- To investigate the effect of substituting corticotrophin for prednisolone in children with chronic asthma.
- To assess the impact on growth patterns in children experiencing prednisolone-induced growth retardation.
Main Methods:
- A cohort of 19 children with chronic asthma was studied.
- Participants had experienced growth retardation during regular prednisolone treatment.
- Growth patterns were monitored after switching treatment to corticotrophin.
Main Results:
- Growth retardation observed in children receiving prednisolone was reversed.
- Substitution with corticotrophin led to an improvement in growth trends.
- The study demonstrated a positive effect of corticotrophin on pediatric growth.
Conclusions:
- Corticotrophin is a viable alternative to prednisolone for managing chronic asthma in children.
- Switching from prednisolone to corticotrophin can mitigate or reverse growth retardation.
- This finding has implications for optimizing long-term asthma management in pediatric populations.
Abstract:
A study of the growth patterns of 19 children with chronic asthma, whose growth had become retarded while they were receiving regular treatment with prednisolone, showed that this trend was reversed after the substitution of corticotrophin.