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Successful aging: from phenotype to genotype.

Stephen J Glatt1, Pamela Chayavichitsilp, Colin Depp

  • 1Veterans Medical Research Foundation, University of California at San Diego, La Jolla, CA 92093-0603, USA. sglatt@ucsd.edu

Biological Psychiatry
|January 11, 2007
PubMed
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Genetic factors significantly influence successful aging, extending beyond mere longevity. This review highlights key genes like APOE and SIRT3 as crucial for future research into healthy aging.

Area of Science:

  • Genetics
  • Gerontology
  • Biomedical Science

Background:

  • Growing interest in human healthspan and successful aging.
  • Limited research on genetic influences beyond longevity.
  • Need for comprehensive genetic analysis of healthy aging.

Purpose of the Study:

  • To systematically review genetic studies on successful aging.
  • To identify genetic factors contributing to healthy aging characteristics.
  • To provide recommendations for future research.

Main Methods:

  • Systematic review of published family, twin, linkage, and association studies.
  • Inclusion criteria: studies evaluating longevity and at least one other healthy aging characteristic.
  • Analysis of 29 eligible studies.

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Main Results:

  • Evidence for a substantial genetic contribution to successful aging.
  • Identification of specific candidate genes: APOE, GSTT1, IL6, IL10, PON1, and SIRT3.
  • Methodological inconsistencies noted across studies.

Conclusions:

  • Genetics plays a significant role in successful aging.
  • Identified genes warrant further molecular genetic investigation.
  • Recommendations provided for advancing the field of aging genetics.