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Is the cyclic AMP in psoriatic epidermis low?
The British Journal of Dermatology
|September 1, 1975
Summary
Psoriatic skin lesions do not show a deficiency in epidermal cyclic adenosine 3
Area of Science:
- Dermatology
- Biochemistry
Background:
- Epidermal cyclic adenosine 3', 5'-monophosphate (cyclic AMP) deficiency was hypothesized to cause psoriatic lesion characteristics.
- These characteristics include incomplete differentiation, increased mitosis, and elevated glycogen concentration.
Purpose of the Study:
- To investigate epidermal cyclic AMP levels in psoriatic lesions versus normal skin.
- To determine if a cyclic AMP deficiency underlies psoriatic lesion development.
Main Methods:
- Improved methodology to prevent local ischemia in biopsy specimens.
- Microdissection of epidermis from dermis for pure epidermal cyclic AMP assay.
- Comparison of cyclic AMP concentration on dry weight, protein, and DNA content bases.
Main Results:
- Epidermal cyclic AMP levels were 20-25% higher in psoriatic lesions compared to uninvolved skin.
- This elevation was consistent across dry weight, protein, and DNA content comparisons.
Conclusions:
- The study refutes the hypothesis of epidermal cyclic AMP deficiency in psoriatic lesions.
- Psoriatic lesion characteristics are not solely attributable to reduced cyclic AMP levels.