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Updated: Jul 17, 2026

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Kojic acid-tripeptide amide as a new tyrosinase inhibitor
Jin-Mi Noh1, Seon-Yeong Kwak, Do-Hyun Kim
1School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea.
Abstract:
Twenty two kojic acid-tripeptide amides were prepared using a solid-phase Fmoc/tBu strategy with Rink Amide SURE(R) resin. To effectively obtain kojic acid-tripeptide amide conjugates, the coupling conditions of kojic acid to the tripeptide on the resin were optimized. The tyrosinase inhibitory activity of kojic acid-tripeptide amides and the effect of the amino acid sequence on the activity were compared with those of kojic acid-tripeptide acids. The stability of kojic acid-tripeptide amides were then compared with those of kojic acid and kojic acid-tripeptides acids. As a consequence, kojic acid-FWY-NH(2) proved to be the best compound, with the highest inhibitory activity, which was maintained over different storage times under various temperatures and pHs.
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