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[Quantitative analysis on Radix Salviae miltiorrhizae by NIR].
Chun-xiang Shi1, Yue-wu Yang, Zhi-xin Guo
1Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials
|January 11, 2007
Summary
Near-infrared (NIR) reflectance spectroscopy offers a rapid, nondestructive method for analyzing key compounds in Radix Salviae Miltiorrhizae. This technique accurately quantifies salvianolic acid B and tanshinone IIA, simplifying quality control for traditional Chinese medicine.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Traditional Chinese Medicine Analysis
Background:
- Radix Salviae Miltiorrhizae is a crucial component in traditional Chinese medicine.
- Accurate quantification of active compounds like salvianolic acid B and tanshinone IIA is essential for quality control.
- Traditional analytical methods can be time-consuming and require complex sample preparation.
Purpose of the Study:
- To develop a rapid and nondestructive method for determining salvianolic acid B and tanshinone IIA content.
- To utilize near-infrared (NIR) reflectance spectroscopy for quantitative analysis.
- To establish a reliable analytical technique for complex traditional Chinese medicine formulations.
Main Methods:
- Quantitative model development using near-infrared diffuse reflectance spectroscopy.
- Validation of the model for accuracy and precision.
- Nondestructive sample analysis to preserve material.
Main Results:
- The root mean square error of prediction (RMSEP) for salvianolic acid B was 0.259.
- The RMSEP for tanshinone IIA was 0.0232.
- The developed NIR method demonstrated high accuracy in quantification.
Conclusions:
- Near-infrared (NIR) spectroscopy provides a rapid, correct, and nondestructive method for analyzing Radix Salviae Miltiorrhizae.
- The technique simplifies sample pretreatment compared to traditional methods.
- NIR is suitable for quality control in the production of complex traditional Chinese medicines.
