Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hepatitis

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

Viruses with RNA Genomes

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Microbiota is essential for social development in the mouse.

Molecular psychiatry·2026

Same author

Safety of <i>Bifidobacterium breve</i>, Bif195, employing a human exercise-induced intestinal permeability model: a randomised, double-blinded, placebo-controlled, parallel group trial.

Beneficial microbes·2022

Same author

Modulation, microbiota and inflammation in the adult CF gut: A prospective study.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2022

Same author

Metagenomic assembled plasmids of the human microbiome vary across disease cohorts.

Scientific reports·2022

Same author

Mapping the colorectal tumor microbiota.

Gut microbes·2021

Same author

The gut virome in Irritable Bowel Syndrome differs from that of controls.

Gut microbes·2021

Search research articles

Related Experiment Video

Updated: Jul 17, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

In vitro replication models for the hepatitis C virus.

P Sheehy¹, B Mullan, I Moreau

¹Department of Medicine, University College Cork, Cork, Ireland. pat_sheehy@yahoo.com

Journal of Viral Hepatitis

|January 11, 2007

Summary

Researchers explored hepatitis C virus (HCV) replication models, from early RNA replicons to current infectious cell culture systems. These advancements are crucial for understanding HCV replication and developing treatments.

More Related Videos

A Protocol for Analyzing Hepatitis C Virus Replication

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Published on: July 16, 2012

Related Experiment Videos

Last Updated: Jul 17, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

A Protocol for Analyzing Hepatitis C Virus Replication

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Published on: July 16, 2012

Area of Science:

Virology
Hepatology
Molecular Biology

Background:

The discovery of the hepatitis C virus (HCV) necessitated the development of robust experimental systems.
Early research relied on indirect methods to study viral replication.
Understanding HCV replication is key to developing effective antiviral therapies.

Purpose of the Study:

To chronologically review the evolution of hepatitis C virus replication models.
To highlight the impact of key models, including the HCV RNA replicon and cell culture systems.
To provide context for ongoing research in HCV virology.

Main Methods:

Literature review of HCV replication models from the early 1990s to present.
Analysis of the development and impact of the HCV RNA replicon system.
Examination of the emergence and utility of infectious HCV cell culture systems.

Main Results:

The development of the HCV RNA replicon model significantly advanced the study of viral replication.
Recent infectious cell culture systems allow for a more comprehensive understanding of the viral life cycle.
These models have been instrumental in identifying potential therapeutic targets.

Conclusions:

The progression of HCV replication models, from RNA replicons to cell culture systems, has been pivotal.
Continued refinement of these models promises further breakthroughs in HCV research.
These advancements are essential for the eventual eradication of hepatitis C.