Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In vitro replication models for the hepatitis C virus.

P Sheehy1, B Mullan, I Moreau

  • 1Department of Medicine, University College Cork, Cork, Ireland. pat_sheehy@yahoo.com

Journal of Viral Hepatitis
|January 11, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Microbiota is essential for social development in the mouse.

Molecular psychiatry·2026
Same author

Safety of <i>Bifidobacterium breve</i>, Bif195, employing a human exercise-induced intestinal permeability model: a randomised, double-blinded, placebo-controlled, parallel group trial.

Beneficial microbes·2022
Same author

Modulation, microbiota and inflammation in the adult CF gut: A prospective study.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2022
Same author

Metagenomic assembled plasmids of the human microbiome vary across disease cohorts.

Scientific reports·2022
Same author

Mapping the colorectal tumor microbiota.

Gut microbes·2021
Same author

The gut virome in Irritable Bowel Syndrome differs from that of controls.

Gut microbes·2021

Researchers explored hepatitis C virus (HCV) replication models, from early RNA replicons to current infectious cell culture systems. These advancements are crucial for understanding HCV replication and developing treatments.

Area of Science:

  • Virology
  • Hepatology
  • Molecular Biology

Background:

  • The discovery of the hepatitis C virus (HCV) necessitated the development of robust experimental systems.
  • Early research relied on indirect methods to study viral replication.
  • Understanding HCV replication is key to developing effective antiviral therapies.

Purpose of the Study:

  • To chronologically review the evolution of hepatitis C virus replication models.
  • To highlight the impact of key models, including the HCV RNA replicon and cell culture systems.
  • To provide context for ongoing research in HCV virology.

Main Methods:

  • Literature review of HCV replication models from the early 1990s to present.
  • Analysis of the development and impact of the HCV RNA replicon system.

Related Experiment Videos

  • Examination of the emergence and utility of infectious HCV cell culture systems.

    • Main Results:

    • The development of the HCV RNA replicon model significantly advanced the study of viral replication.
    • Recent infectious cell culture systems allow for a more comprehensive understanding of the viral life cycle.
    • These models have been instrumental in identifying potential therapeutic targets.

    Conclusions:

    • The progression of HCV replication models, from RNA replicons to cell culture systems, has been pivotal.
    • Continued refinement of these models promises further breakthroughs in HCV research.
    • These advancements are essential for the eventual eradication of hepatitis C.