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Infectious keratitis following keratoplasty
Rasik B Vajpayee1, Namrata Sharma, Rajesh Sinha
1Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Survey of Ophthalmology
|January 11, 2007
Summary
Corneal graft infections after transplantation are a major cause of graft failure, particularly within the first year. Early risk factor management may improve outcomes, though visual prognosis remains poor.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Transplantation
Background:
- Infectious keratitis is a primary cause of corneal graft failure.
- Graft infection incidence varies globally, with higher rates in developing nations.
- Most infections occur within one year post-transplantation.
Purpose of the Study:
- To review the incidence, risk factors, causative organisms, and outcomes of infectious keratitis following corneal transplantation.
- To highlight the importance of early identification and management of risk factors for improving graft survival.
Main Methods:
- Literature review focusing on infectious keratitis post-keratoplasty.
- Analysis of incidence rates, common risk factors, and microbial profiles.
- Evaluation of treatment outcomes and visual prognosis.
Main Results:
- Suture issues and persistent epithelial defects are key risk factors.
- Common pathogens differ between developed (Pneumococcus, Staphylococcus aureus) and developing (Staphylococcus epidermidis) countries.
- Poor visual prognosis and high graft decompensation rates are observed even with treatment.
Conclusions:
- Early detection and management of risk factors are crucial for preventing graft infection and enhancing survival.
- Infectious keratitis significantly impairs visual outcomes after corneal transplantation.
- Understanding regional microbial differences is important for targeted prevention and treatment strategies.
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