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Related Experiment Videos

Infiltrating giant cellular blue naevus.

A L Bittencourt1, D A Monteiro, O J De Pretto

  • 1Department of Pathology, Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil. achilea@uol.com.br

Journal of Clinical Pathology
|January 11, 2007
PubMed
Summary
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Giant cellular blue nevi (GCBN) can deeply infiltrate facial structures, including bone and sinuses, without showing malignancy. Immunohistochemical analysis confirmed the benign nature of this extensive tumor in a young patient.

Area of Science:

  • Dermatopathology
  • Oncology
  • Surgical Pathology

Background:

  • Cellular blue nevi (CBN) are typically benign dermal lesions, measuring 1-2 cm.
  • Giant cellular blue nevi (GCBN) are rare, larger variants with potential for extensive local invasion.

Observation:

  • A rare case of a giant cellular blue nevus (GCBN) in a 14-year-old boy involving the face, sinuses, and bone is presented.
  • The tumor infiltrated the dermis, subcutaneous fat, skeletal muscle, bone, jugal mucosa, and maxillary sinus.

Findings:

  • Immunohistochemical evaluation revealed a biphasic pattern with tumor cells positive for HMB-45, anti-S100, and A-103, but negative for CD34, CD56, and MIB-1.
  • Melan A showed focal expression, and importantly, no histological evidence of malignancy was found despite deep infiltration.

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Implications:

  • This case highlights the significant infiltrative capacity of GCBN, emphasizing the need for thorough diagnostic evaluation.
  • Accurate diagnosis through immunohistochemistry is crucial to differentiate GCBN from malignant neoplasms, guiding appropriate clinical management.