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Thyroidectomy for Graves' disease: a case-control study.

Joshua L Scharf1, Sidrah M Ahmad, John P Gaughan

  • 1Department of Otolaryngology-Head and Neck Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

The Annals of Otology, Rhinology, and Laryngology
|January 12, 2007
PubMed
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Thyroidectomy for Graves' disease showed similar outcomes to other thyroid surgeries. However, patients with persistent hyperthyroidism undergoing surgery experienced more complications.

Area of Science:

  • Endocrinology
  • Surgical Oncology

Background:

  • Radioactive iodine is the primary Graves' disease treatment in the US.
  • Thyroidectomy for Graves' disease is uncommon and considered technically challenging.

Purpose of the Study:

  • To compare surgical outcomes of thyroidectomy in Graves' disease patients versus non-Graves' disease patients.
  • To identify potential differences in length of hospital stay, operative time, and blood loss.

Main Methods:

  • Retrospective chart review of Graves' disease patients undergoing thyroidectomy (1997-2005).
  • Comparison with age- and thyroid size-matched control group without Graves' disease.
  • Statistical analysis of operative time, blood loss, and hospital stay.

Main Results:

Related Experiment Videos

  • No significant differences in operative time, blood loss, or hospitalization between groups.
  • Complications occurred in 3 of 11 Graves' disease patients.
  • All complications were in patients with persistent hyperthyroidism at the time of surgery.

Conclusions:

  • Thyroidectomy can be safely performed in selected euthyroid Graves' disease patients.
  • Persistent hyperthyroidism in Graves' disease patients undergoing surgery is associated with increased complications.