Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing treatment strategies for femoral neck fractures using a machine learning model.

Journal of orthopaedic surgery and research·2026
Same author

Enhanced PIEZO1 expression in mast cells of mastocytosis skin lesions: Relevance to Darier's sign.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

3D imaging reveals robustness and plasticity of cell division in rice early embryogenesis.

Plant & cell physiology·2025
Same author

Antitumor Effect of Selumetinib for Brainstem Glioma in an Adult With NF1: A Case Report.

Neurosurgery practice·2025
Same author

<i>Oryza sativa</i> Baby Boom1 converts the developmental fate of rice egg cells from gametic into somatic status.

iScience·2025
Same author

Response to 'MISSLE in melanoma: Promise, limitations and the need for broader validation'.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025

Related Experiment Video

Updated: Jul 17, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

NF-kappaB and rheumatic diseases.

Takashi Okamoto1

  • 1Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan. tokamoto@med.nagoya-cu.ac.jp

Endocrine, Metabolic & Immune Disorders Drug Targets
|January 12, 2007
PubMed
Summary

Nuclear Factor-kappa B (NF-kappaB) drives inflammation and is implicated in rheumatic diseases and cancer. Targeting NF-kappaB offers a potential therapeutic strategy for these conditions.

Area of Science:

  • Immunology
  • Molecular Biology
  • Rheumatology

Background:

  • Nuclear Factor-kappa B (NF-kappaB) is a crucial inducible transcription factor regulating genes involved in inflammation, cell cycle, apoptosis, and cell adhesion.
  • Constitutive activation of NF-kappaB is observed in chronic inflammatory conditions like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
  • NF-kappaB activation is also linked to carcinogenesis, with its constitutive activation found in certain cancers and leukemias.

Purpose of the Study:

  • To review the pathological role of NF-kappaB in rheumatic diseases.
  • To discuss the therapeutic potential of targeting NF-kappaB and its signaling pathways.

Main Methods:

  • Literature review of NF-kappaB's involvement in rheumatic diseases and cancer.

Related Experiment Videos

Last Updated: Jul 17, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

  • Analysis of existing data on anti-NF-kappaB compounds and their efficacy.
  • Discussion of NF-kappaB signaling cascades as therapeutic targets.

    • Main Results:

    • NF-kappaB plays a significant role in the pathogenesis of rheumatic diseases.
    • Compounds targeting NF-kappaB show potential in treating RA.
    • The link between chronic inflammation, autoimmunity, and carcinogenesis is molecularly substantiated by NF-kappaB's role.

    Conclusions:

    • NF-kappaB is a key mediator in the pathology of rheumatic diseases.
    • Targeting NF-kappaB signaling presents a promising therapeutic avenue for rheumatic conditions and potentially cancer.
    • Understanding NF-kappaB's molecular mechanisms is vital for developing novel treatments.