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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

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SeqHepB: a sequence analysis program and relational database system for chronic hepatitis B.

Lilly K W Yuen1, Anna Ayres, Margaret Littlejohn

  • 1Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, 3051 Vic., Australia. lilly.yuen@mh.org.au

Antiviral Research
|January 12, 2007
PubMed
Summary

SeqHepB analyzes Hepatitis B virus (HBV) genomes, identifying genotypes and mutations linked to drug resistance. This tool integrates genomic data with clinical records for personalized patient management and research.

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Area of Science:

  • Hepatology
  • Virology
  • Bioinformatics

Background:

  • Hepatitis B virus (HBV) infection poses a significant global health challenge.
  • Managing HBV requires understanding viral genotypes, mutations, and antiviral resistance.
  • Integrating diverse data sources is crucial for effective HBV patient care and research.

Purpose of the Study:

  • To introduce SeqHepB, a novel integrated system for HBV genome sequence analysis and data management.
  • To enable rapid identification of HBV genotypes, drug resistance mutations, and clinically significant mutants.
  • To facilitate correlation of clinical, virological, and phenotypic data for personalized medicine and research.

Main Methods:

  • SeqHepB combines a HBV genome sequence analysis program with a relational database.
  • Data integration includes patient medical records, lab tests, and in vitro drug resistance values.
  • Utilizes Structured Query Language (SQL) for efficient data extraction and correlation.
  • Incorporates a 3D model visualization of HBV reverse transcriptase (RT) with drug molecules.

Main Results:

  • SeqHepB provides rapid and detailed interrogation of HBV genomic sequences.
  • Identifies HBV genotypes, key mutations associated with antiviral resistance, and clinically important mutants.
  • Enables efficient correlation of clinical, virological, and in vitro phenotypic data.
  • Offers 3D visualization of mutations on the HBV RT enzyme structure.

Conclusions:

  • SeqHepB empowers virologists and physicians to individualize patient management for HBV.
  • Facilitates coping with the increasing number of antiviral-associated HBV mutations.
  • Supports retrospective and prospective studies on HBV-infected individuals during therapy.