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Insights into TRPM4 function, regulation and physiological role.

R Vennekens1, B Nilius

  • 1Laboratory of Physiology, Katholieke Universiteit Leuven, Campus Gasthuisberg O/N1, Herestraat 49-Bus 802, 3000 Leuven, Belgium. rudi.vennekens@med.kuleuven.be

Handbook of Experimental Pharmacology
|January 16, 2007
PubMed
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This review details the molecular and functional properties of TRPM4 channels, which are calcium-activated, non-selective cation channels. Their role in regulating membrane potential and calcium influx is increasingly understood.

Area of Science:

  • Molecular biology
  • Cell physiology
  • Ion channel function

Background:

  • TRPM4 and TRPM5 are the only known molecular candidates for Ca2+-activated non-selective cation channels.
  • These channels are impermeable to Ca2+ but are activated by elevated intracellular Ca2+ levels.

Purpose of the Study:

  • To review and summarize recent literature on the molecular and functional properties of TRPM4.
  • To discuss the determinants of TRPM4 channel activation, permeation, and modulation.

Main Methods:

  • Literature review of recent studies on TRPM4.
  • Analysis of molecular and functional data from published research.

Main Results:

  • TRPM4 activation depends on intracellular Ca2+ and membrane potential.

Related Experiment Videos

  • Channel activity is modulated by ATP, PiP2, PKC phosphorylation, and heat.
  • Molecular mechanisms underlying TRPM4 function are becoming clearer.

    • Conclusions:

    • TRPM4 channels play a role in regulating membrane potential.
    • This regulation influences the driving force for extracellular Ca2+ entry.
    • The precise physiological role of these channels requires further investigation, particularly in the absence of gene-specific knock-out models.