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SRC-p300 coactivator complex is required for thyroid hormone-induced amphibian metamorphosis

Bindu D Paul1, Daniel R Buchholz, Liezhen Fu

  • 1Laboratory of Gene Regulation and Development, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA.

The Journal of Biological Chemistry
|January 16, 2007
PubMed
Summary

Thyroid hormone receptor (TR) coactivators are crucial for development. This study shows p300/CREB-binding protein (CBP) is essential for TR function during Xenopus laevis metamorphosis, highlighting its role in gene activation.

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