Related Experiment Video
Updated: Jul 17, 2026

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
Published on: August 23, 2022
Bile duct perforation in children: is it truly spontaneous?
T R Sai Prasad1, Chan Hon Chui, Yee Low
1Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore. trsai@rediffmail.com
Insights
Bile duct perforation (BDP) in children, often linked to anomalous pancreaticobiliary union (AUPBD) and choledochal cysts, requires surgical intervention. Early diagnosis and treatment are crucial for successful outcomes in these rare cases.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Anatomical Abnormalities
Background:
- Bile duct perforation (BDP) with biliary ascites is a rare pediatric condition.
- Anomalous union of the pancreaticobiliary ductal (AUPBD) system is increasingly implicated in BDP aetiopathogenesis.
Observation:
- Presents two pediatric cases of spontaneous bile duct perforation, histopathologically diagnosed as choledochal cysts.
- Patients, a 6-month-old female and a 4-year-old boy, exhibited subtle clinical symptoms.
Findings:
- Both patients underwent successful surgical management involving excision of the gallbladder and common bile duct with Roux-en-Y hepaticojejunostomy.
- One patient initially received cholecystostomy drainage before definitive surgery.
Implications:
- Suggests BDP in children may be associated with AUPBD and choledochal cysts, challenging the notion of purely spontaneous perforation.
- Highlights the importance of considering these underlying conditions in the diagnosis and management of pediatric BDP.
Introduction:
Bile duct perforation (BDP) with resultant biliary ascites in children is a rare clinical condition. The aetiopathogenesis is still an enigma, with increasing evidence suggesting anomalous union of pancreaticobiliary ductal (AUPBD) system as the prime causative factor.
Clinical Picture:
We report 2 cases of spontaneous perforation of the bile duct confirmed on histopathological examination as choledochal cyst, in a 6-month-old female child and a 4-year-old boy who presented with subtle clinical symptoms.
Treatment And Outcome:
Both patients were successfully managed by excision of the gall bladder and common bile duct and Roux-en- Y hepaticojejunostomy. This procedure was performed following initial cholecystostomy drainage in the second case.
Conclusions:
From the available literature and experience with our patients, BDP is not merely spontaneous but may be related to AUPBD and choledochal cyst.
Related Concept Videos
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus.
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Cholecystitis
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
