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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Gastric mucosal Helicobacter pylori distribution and its implications
H K Dabbous1, E A El Fekhfakh, A M Badr
1Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo.
The Journal of the Egyptian Public Health Association
|January 16, 2007
Summary
Helicobacter pylori (H. pylori) infection significantly impacts chronic gastritis severity and activity in the stomach's antrum and body. Even H. pylori-negative patients can exhibit atrophic gastritis and intestinal metaplasia.
Area of Science:
- Gastroenterology
- Pathology
- Microbiology
Background:
- Helicobacter pylori (H. pylori) is a common pathogen linked to various gastric diseases.
- Understanding the clinicopathological impact of H. pylori across different stomach regions is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the clinicopathological features of H. pylori infection in various stomach locations.
- To correlate H. pylori colonization grades with gastritis severity and activity.
Main Methods:
- Histopathological examination of gastric biopsies from 36 patients.
- Modified Giemsa stain for H. pylori confirmation.
- Grading of chronic gastritis based on mononuclear cell infiltration, severity, and activity.
Main Results:
- H. pylori positivity was observed in 77.8% of patients.
- Significant differences in chronic gastritis severity and activity were found in the antrum and body compared to the fundus in H. pylori-positive patients.
- A significant correlation was established between H. pylori colonization grade and chronic active gastritis, as well as atrophic gastritis.
Conclusions:
- H. pylori infection significantly influences the severity and activity of chronic gastritis in the gastric antrum and body.
- Atrophic gastritis and intestinal metaplasia can occur in H. pylori-negative individuals, potentially due to a mucosa that has become inhospitable to the bacteria.
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