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Neoplastic meningitis.

S A Grossman1, T J Moynihan

  • 1Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Neurologic Clinics
|November 1, 1991
PubMed
Summary

Neoplastic meningitis, a cancer complication, is increasing. Treatment involves intrathecal chemotherapy, radiation therapy, and systemic cancer management, with ongoing research to improve efficacy and reduce toxicity.

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Area of Science:

  • Oncology
  • Neurology
  • Cancer Metastasis

Background:

  • Neoplastic meningitis (NM) incidence is rising due to improved cancer survival rates.
  • NM is frequently observed in leukemia, breast, lymphoma, and small cell lung cancers, but can occur with any malignancy.
  • This complication significantly impacts patient prognosis and quality of life.

Purpose of the Study:

  • To summarize current understanding and management strategies for neoplastic meningitis.
  • To highlight the increasing prevalence of NM in cancer patients.
  • To discuss ongoing research for improved treatment efficacy and reduced toxicity.

Main Methods:

  • Review of current literature on neoplastic meningitis.
  • Analysis of treatment modalities including intrathecal chemotherapy, radiation therapy, and systemic cancer care.
  • Discussion of emerging therapeutic strategies.

Main Results:

  • Neoplastic meningitis is an increasingly recognized complication across various cancer types.
  • Effective management requires a multimodal approach targeting the central nervous system (CNS) and systemic disease.
  • Current treatments aim to control leptomeningeal disease and alleviate symptoms.

Conclusions:

  • Multidisciplinary management is crucial for patients with neoplastic meningitis.
  • Further research is needed to develop more effective and less toxic therapies for NM.
  • Improving outcomes for NM is essential for enhancing the overall care of cancer patients.

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