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Published on: August 15, 2025
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Peripheral granular cell odontogenic fibroma
Joseph Rinaggio1, Deborah Cleveland, Ranie Koshy
1Department of Diagnostic Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark, NJ 07103-2400, USA. rinaggjo@umdnj.edu
Summary
Peripheral granular cell odontogenic fibroma is a rare gingival lesion. This case report details a symptomatic mandibular lesion, highlighting its unique cellular composition and rarity in medical literature.
Area of Science:
- Oral pathology
- Odontogenic tumors
- Gingival lesions
Background:
- Peripheral odontogenic fibroma is a rare gingival lesion.
- It can clinically mimic other oral pathologies, including reactive lesions, benign neoplasms, and metastases.
- Accurate diagnosis is crucial for appropriate management.
Observation:
- A symptomatic lesion on the mandibular gingiva of a 58-year-old female was analyzed.
- The patient had no history of trauma or prior dental disease in the affected area.
- Clinical presentation mimicked various other oral conditions.
Findings:
- Excisional biopsy revealed a peripheral granular cell odontogenic fibroma.
- The stroma contained numerous polyhedral granular cells.
- Interspersed islands of inactive odontogenic epithelium were noted.
Implications:
- This represents the fourth detailed case report of peripheral granular cell odontogenic fibroma in the literature.
- The findings contribute to understanding the histopathological spectrum of rare odontogenic tumors.
- Increased awareness may improve diagnostic accuracy for similar challenging gingival lesions.
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