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Plasma Cell Mucositis: A Clinical Conundrum.

Mahnaz Fatahzadeh¹, Joseph Rinaggio, Robert A Schwartz

¹Mahnaz Fatahzadeh, DMD, MSD, Rutgers School of Dental Medicine, 110 Bergen Street, Newark, United States of America; fatahza@sdm.rutgers.edu.

Acta Dermatovenerologica Croatica : ADC

|July 1, 2024

Summary

Plasma cell mucositis (PCM) is a rare disorder affecting mucous membranes, characterized by plasma cell proliferation. Treatment involves trigger avoidance and steroid therapy for this complex condition.

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Area of Science:

Oral Medicine
Dermatology
Pathology

Background:

Plasma cell mucositis (PCM) is an uncommon condition affecting accessible mucosal surfaces.
It is frequently observed in the upper aerodigestive tract but can manifest in various anatomical sites.
Specific presentations include plasma cell cheilitis, gingivitis, vulvitis, and Zoon's balanitis.

Purpose of the Study:

To review and update current knowledge on plasma cell mucositis.
To discuss the diagnostic challenges and clinical presentation of PCM.
To summarize therapeutic approaches for managing PCM.

Main Methods:

Literature review of plasma cell mucositis.
Analysis of clinical and pathological features.
Synthesis of treatment strategies.

Main Results:

PCM is characterized by a dense polyclonal plasma cell infiltrate.
The etiology of PCM remains unclear.
Management typically involves identifying and avoiding triggers, alongside intralesional or systemic steroid administration.

Conclusions:

Plasma cell mucositis presents a diagnostic and therapeutic challenge.
Understanding the polyclonal nature of the plasma cell proliferation is key.
Multifaceted treatment approaches are often necessary for effective management.