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Relationship between DNA methylation and cell proliferation in Trypanosoma cruzi
1Department of Cell Biology and Genetics, School of Medicine, University of Chile, Santiago.
FEBS Letters
|December 16, 1991
Abstract:
5-Azacytidine treatment of T. cruzi epimastigotes in culture induces active cell proliferation. This effect was detected as an increase in the cell number and [3H-methyl]thymidine incorporation into DNA. 5-Azacytidine does not alter other metabolic parameters. We have previously demonstrated that 5-azacytidine induces DNA hypomethylation in T. cruzi. Accordingly, we suggest that this chemical modification may be related to the control of T. cruzi cell division.