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Induction of apoptotic cell death by a ceramide analog in PC-3 prostate cancer cells

Ji Eun Oh1, Kwang Sup So, Se Jin Lim

  • 1College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.

Archives of Pharmacal Research
|January 18, 2007
PubMed

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
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