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Published on: November 11, 2022
[Studies on HPLC fingerprint of cortex moutan]
Shun-Jun Xu1, Peng Li, Liu Yang
1Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China.
Objective:
To establish a HPLC fingerprint for quality evaluation of Cortex Moutan.
Method:
The HPLC chromatographic fingerprinting of 30 lots of Cortex Moutan was established and major peaks were identified by LC-MS and MS-MS.
Result:
The HPLC fingerprint of Cortex Moutan was established, showing 15 characteristic peaks. The areas of these peaks were found to complied with the following rule: paeonol > 1, 2, 3, 4, 6-penta-O-galloyl-glucos > methyl gallate > galloylpaeoniflorin > gallic acid > oxypaeoniflorin > other compounds.
Conclusion:
The chromatographic fingerprinting of Cortex Moutan with high specificity can be used to control its quality and monitor lot to lot consistency.
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