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Updated: Jul 17, 2026

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments
Published on: May 9, 2019
[Study on the preparation and quality standard of Ephedra sinica dispensing granules]
Bin Zhou1, Wen-Yuan Gao, Tie-Jun Zhang
1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. super_zhou@eyou.com
Objective:
To optimize the preparation process and to set up the quality standard of Ephedra sinica Dispensing Granules.
Methods:
Nine experiments were carried out by L9 (3(4)) orthogonal design. Ephedra sinica Dispensing Granules was identified by TLC and the content of ephedrine was determined by HPLC.
Results:
The optimal extraction process was as follows: the water that 10 times of Ephedra sinica, was decocted 3 times and each time was sustained for 1.5 hours. The linear relationship of ephedrine hydrochloride was at the range of 0.0081 - 0.1377 microg (r = 0.999 9). The average recovery was 100.25% ( RSD = 2.24%, n = 6).
Conclusion:
The extraction process is scientific. The method is available with a good reproducibility and can control the quality of Ephedra sinica Dispensing Granules.
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